Segment Your Tasks
Instead of trying to tackle your whole house (or every aspect of your life) at once, focus on smaller, more manageable projects that will offer big gratification once completed. Set aside a day or an afternoon to work on something and try not to think about the other areas of your life that need attention. Just focus on getting this task finished.
Such a seemingly never-ending task can be overwhelming at times. Keep your focus by setting specific goals. Give yourself an hour (or two) to accomplish a task. Perhaps you aim to fill one trash bag of junk every week. Or maybe you simply need to commit to having a specific room finished by a certain date.
Aim for the
If you've been good about clearing out clothes you don't wear and not letting junk mail pile up, opt for areas in your life that are overlooked but could use some cleaning up. When was the last time you striped your bed (mattress cover, dust ruffle, duvet, etc.) and washed everything while emptying out whatever's been lurking under the bed? Or perhaps that medicine cabinet, overflowing with nearly-empty tubes and expired medicine, could be cleaned out and organized.
Bring It to Work
Take everything off the top of your desk. Give it a full wipe down and then start putting the items back, deciding if it needs to be there. This is when we tend to find a lot of out-of-date items that were being saved for a time that's since passed. Some personal items add character and may keep you motivated but too much clutter will suffocate your productivity. Give yourself room to work.